Volumen: 5 # Number : 1
Publication Date : Enero - Abril Year: 2001
Authors: Débora V. Breier, Pablo Rendo, Jaqueline G. Gonzalez, Sofia Golztein
Abstract: They summarize The secondary pancitopenia to anemia aplástica it is a rare complication of the treatment with tionamidas, where the bony marrow proves invariably hipocelular. Let's sense beforehand a 16-year-old patient of age with disease of Serious, that I develop plasmocitosis massive secondary to metimazol simulating mieloma multiply. The patient had received metimazol for one month, when he presents a compatible picture for sepsis, for that he penetrates. Inhaled of bony marrow realized to the diagnosis they show marrow I hiccup to normocelular with 98 % of plasmatic cells. To his revenue, the administration suspends antibiotics of wide spectrum. Dexametasona and G-CSF. Inhaled fundamental of the +4th it shows marrow I hiccup - normocelular, with 6 % of plasmocitos remnants. The citometría of flow boss confirms policlonal. The screening for mieloma turns out to be negative. ANC> 1000mm2 a +7th, platelets> 5000/mm3 on the +24th. To 24 months of the discharge, the patient presents clinic, bony marrow, I study citogénico and smears of blood peripheral normal. In our knowledge, this one is the first report of pancitopenia secondary to metimazol where the awaited fundamental hipoplasia was replaced by a bony marrow with plasmocitos massive. This boss of toxicity, of aparción exceptional forces to the differential diagnosis with mieloma multiply not secretor, of treatment and different forecast.
Key words: Plasmocytosis, Methimazole, Thionamide
Pages : 24-27
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