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Revista Argentina de Hematología

Abstract

Volumen:    22    # Number : Numero Extraordinario XIII Congreso del Grupo CAHT

Publication Date :    Septiembre    Year:    2018

   IV CURSO EDUCACIONAL DE LA ISTH - BLOQUE 1 PEDIATRÍA

The neonatal thrombosis paradox

Authors: Nugent D

Abstract: There is no better example of the nuances and short comings of our laboratory assays to predict bleeding, than neonatal coagulation. Paradoxically, very prolonged partial thromboplastin time and protime assays are the “norm” for a term neonate and maybe even further prolonged in the premature infant, and yet these, our very youngest patients, are considered more likely to experience a thrombotic event, rather than bleed(1,2). Indeed, based on the most recent registries, the rate of thrombosis in this age group is 10 fold that of a child 12 months or greater, with coagulation studies in normal range(3). Understanding the shifts from fetal/newborn production of both clotting factors and those factors responsible for slowing the rate of thrombus formation, along with the equally challenging developmental alterations in platelet function, is key in the proper evaluation of the high-risk neonate and in determination of optimal therapy.

Key words: neonatal thrombosis, stroke, perinatal risk factors

Pages : 217-224

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