Sociedad Argentina de Hematología

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Revista Argentina de Hematología


Volumen:    22    # Number : Numero Extraordinario XIII Congreso del Grupo CAHT

Publication Date :    Septiembre    Year:    2018


Optimal duration of secondary prevention of VTE

Authors: Ageno W

Abstract: Recurrent venous thrombosis may occur within the first few days or weeks, but also after several months or years after the index event. Observational studies have reported that up to 40% of patients will experience a recurrence after 8 to 10 years(1). The incidence rate of recurrent VTE was estimated to be about 5.0% patient-years, being highest during the first 6 months (11.0% patient-years) and then decreasing with a plateau at 2.2% patient-years between 4 and 10 years after the index event(2). Recurrence rates are highest in patients with permanent predisposing factors, such as active cancer, and lowest in patients with major, removable predisposing factors such as surgery(3,4). In between, there are several subgroups of patients including those with chronic inflammatory diseases, patients with non-surgical removable risk factors such as hormonal therapy or acute medical illness, and patients with unprovoked VTE(5). It was proposed that a recurrence rate of 5% at one year and of 15% at five years after stopping anticoagulant therapy can be considered acceptable to justify discontinuation of vitamin K antagonists (VKAs), whereas higher recurrence rates should mandate continuation of treatment

Key words: vitamin K antagonists, direct oral anticoagulants, venous thromboembolism.

Pages : 50-53

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