Sociedad Argentina de Hematología

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Revista Argentina de Hematología


Volumen:    22    # Number : 2

Publication Date :    Mayo - Agosto    Year:    2018


Chronic myeloid leukemia and tirosinkinase inhibitors: toxicity profile. Interruption of treatment and its effects on outcome. Prospective study in a single institution

Authors: Riva ME, Manciola F, Gutiérrez R, Isnardi S, Zoppegno L

Abstract: The development of TKIs has meant a big step in oncohematology leading to a normal life expectancy in CML patients. Adherence is a requirement to achieve sustained deep responses. Adverse events (AE) may compromise the continuity of treatment by interfering with QoL, precluding optimal outcomes. Deep knowledge of ITKs´ toxicity is essential in daily medical practice in order to manage AE and favor patient´s compliance. Although data regarding the development of second malignancies are contradictory, they are among the most common causes of death in this population.

Key words: CML, TKI, toxicity.

Pages : 157-163

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