Sociedad Argentina de Hematología

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Revista Argentina de Hematología


Volumen:    22    # Number : 2

Publication Date :    Mayo - Agosto    Year:    2018


First study on Factor V Leiden detection in Nicaraguan patients with unprovoked venous thromboembolism: Preliminary report

Authors: Montealegre L, Ruiz W, Estrada S, García K, Santamaría C, Puller A, Pernudy A

Abstract: Factor V Leiden (FVL) is the most common genetic thrombophilia. It is constituted by the substitution of a guanine by an adenine in nucleotide 1691 of the gene coding for the coagulation factor V. As a result, the regulatory mechanisms of hemostasis are altered with predominance of procoagulant mechanisms. A cross-sectional study was carried out in 21 patients with a diagnosis of unprovoked vein thromboembolism. The processing of the biological samples was performed by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP). The FVL was detected in 14.3% of studied patients, all with heterozygous genotype. This preliminary report is the first study on Nicaraguan patients with venous thrombosis and the observed FVL frequency is comparable with previous reports from Latin America countries.

Key words: factor V Leiden, genetic thrombophilia, venous thromboembolism.

Pages : 193-196

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