Sociedad Argentina de Hematología

ISSN 2250-8309


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Revista Argentina de Hematología


Volumen:    21    # Number : 3

Publication Date :    Septiembre - Diciembre    Year:    2017


Autoinmune hemolytic anemia as initial manifestation of low‐grade‐B‐cell lymphoma: a diagnostic and therapeutic challenge

Authors: Parra S, Goyanarte B, Cazap N, Gotta D, Altuve J, Huber M, García A, Alsina MF, Avagnina A, Denninghoff V, Cuello MT, Dupont J.

Abstract: Hairy cell leukemia (LCV) and splenic marginal zone lymphoma (LME) are two lymphoproliferative disorders that usually have in common a similar clinical presentation with splenomegaly, cytopenias and an indolent clinical course. It is essential to make a proper differential diagnosis, since the therapeutic approach and prognosis differ between both entities. LCV responds to treatment with nucleoside analogs, while LME treatment options include splenectomy or rituximab. The diagnostic approach includes imaging studies, flow cytometry and pathology of bone marrow, although the results of these methods are not always conclusive. We report a clinical case that had an acute and severe presentation, with autoimmune hemolytic anemia and it also implied a diagnostic challenge in which the use of a novel method was helpful to arrive to a definitive diagnosis and an accurate treatment.

Key words: low grade lymphoma, autoimmune hemolytic anemia, splenic marginal zone lymphoma, BRAF V600E, hairy cell leukemia.

Pages : 317-323

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