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Revista Argentina de Hematología

Abstract

Volumen:    21    # Number : XXIII Congreso Argentino de Hematología

Publication Date :    Noviembre    Year:    2017

   POLIGLOBULIAS NO CLONALES

Is it possible to compensate for hypoxia without elevating hemoglobin?

Authors: Merelli A, Lazarowski A

Abstract: “Hypobaric hypoxia” can limit physical functional capacity, reproductive health and even survival. Consequently, a natural selection of genetic variants that give hypoxia adaptation advantage must have occurred to explain how several populations can live to 3,000-4,000 mts above sea level. Such genetic signatures, recently described in villages living in Ethiopia or in the Andean regions, may alter function and increase Hb concentrations. On the other hand, the tibetans show no elevation of Hb. In them, other genetic variants altered energy performance, respiratory rate and blood flow as the adaptive way of living in these conditions.

Key words: Hypoxia, HIF1/2, ELGN1.

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