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Revista Argentina de Hematología


Volumen:    21    # Number : 2

Publication Date :    Mayo - Agosto    Year:    2017


First generation FLT3 inhibitors sorafenib and midostaurin in acute myeloid leukemia

Authors: Fernández I I

Abstract: FLT3 is one of the most commonly mutated genes in AML, in about 30% of patients (pts). The most frequent mutation that confers poor prognosis is tandem duplication within the juxtamembrane domain of that receptor (FLT3-ITD). Less frequently, point mutations of the tyrosine kinase (TK) domain are detected. Sorafenib and midostaurin are inhibitors of multikinases, not specific for FLT3 mutations and have been evaluated as monotherapy with transient responses in relapsed or refractory (r/r), possibly due to lack of potency and specificity. The results of recent clinical trials show the potential benefit of the ITKs in pts with newly diagnosed AML in combination with standard chemotherapy for induction, consolidation, maintenance and posttransplantation.

Key words: FLT3 inhibitors, Sorafenib, Midostaurin, Acute myeloid leukemia.

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