Sociedad Argentina de Hematología

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Revista Argentina de Hematología


Volumen:    21    # Number : 1°er Cong. de Trasplante de Células Progenitoras Hematopoyéticas - 2°do Congreso del LABMT

Publication Date :    Marzo    Year:    2017


Who is the best alternative allotransplant donor?

Authors: Gale RP; Eapen M

Abstract: Assuming that most physicians will chose an HLAidentical sibling as the best allotransplant donor, the question arises who is the best alternative donor when an HLA-identical sibling is unavailable? The most commonly used alternative donors are HLAidentical or -mismatched unrelated donors, HLAmatched or -mismatched umbilical cord blood donor or a related, HLA-haplotype-matched related donor. Each alternative donor option has advantages and disadvantages. We discuss selected aspects of these issues based on data from randomized clinical trials and observational databases. However, because there are limited data to address specific clinical settings, quantification of expert opinion is sometimes needed. Bone Marrow Transplantation (2015) 50, S40–S42; doi:10.1038/bmt.2015.94 This article was published as part of a supplement, supported by WIS-CSP Foundation, in collaboration with Gilead, Milteny Biotec, Gamida Cell, Adienne Pharma and Biotech, Medac Hematology, Kiadis Pharma and Almog Diagnostic.

Key words: Allotransplant, Unrelated donor, Umbilical cord blood donor, HLA-haplotype-matched related donor

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