Sociedad Argentina de Hematología

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Revista Argentina de Hematología


Volumen:    21    # Number : 1

Publication Date :    Enero - Abril    Year:    2017


Screening of thrombophilia in Latin America

Authors: Guillermo C, Blanco AN, Echenagucia M, García DN, Steffano B, Mérola V, Grille S, Turcatti P, Stevenazzi M, Díaz L, Martínez M.

Abstract: In order to know which algorithms are applied to study thrombophilia in patients with first venous thromboembolic event, a survey was sent (March to April 2016) to the members of the Latin American Cooperative Group on Hemostasis and Thrombosis, Argentine Group on Hemostasis and Thrombosis, Uruguayan Society of Hematology, Uruguayan Society of Internal Medicine, Hemostasis and Thrombosis Unit, School of Medicine, Montevideo, Uruguay. We asked about tests requested in four different clinical situations: unprovoked event in adult <50 (A) or >50 years old (B); provoked event in adult <50 (C) or >50 years old (D). A total of 169 physicians were surveyed, from Uruguay (43.2%), Argentina (17.4%), Brazil (8.3%), Peru (6.8%), Venezuela (6.8%) and other countries (17.5%). Group A: 74-81% request inherited thrombophilia (IT) and 80% antiphospholipid antibodies (APA); a high number of requests for thermolabile variant of MTHFR (29%) and PAI’s polymorphisms (15%) were observed. Group B: 78% request cancer screening and 64% APA; a high number of participants request for homocysteinemia (44%) and IT (28-36%). Group C: 45% request APA and 41% do not request any tests, 27-36% requested IT. Group D: 68% request cancer screening. The survey shows the need for educational actions to eliminate incorrect request by adapting the International Guidelines to the region, which will result in considerable social and economic benefits.

Key words: thrombophilia, thrombosis etiology, diagnostic procedures.

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